Harry Potter (Daniel Radcliffe) ja és al sisè curs de Hogwarts, que tornarà a ser molt especial. Primer, per l'arribada d'un nou professor anomenat Horace Slughorn (Jim Broadbent). I segon, per la troballa d'un llibre de receptes per elaborar pocions màgiques que van pertànyer al misteriós príncep Half-Blood.
Guió: Steve Kloves
Novel·la original: J.K. Rowling
Producció: David Barron, David Heyman
Producció associada: Tim Lewis
Producció executiva: Lionel Wigram
Música: Nicholas Hooper
Fotografia: Bruno Delbonnel
Muntatge: Mark Day
Càsting: Fiona Weir
Disseny de producció: Stuart Craig
Direcció artística: Andrew Ackland-Snow, Alastair Bullock, Molly Hughes, Tino Schaedler, Hattie Storey, Gary Tomkins, Sloane U'Ren
Vestuari: Jany Temime
Maquillatge: Susan Adams, Amanda Burns, Amy Byrne, Louise Coles, Mark Coulier, Francesca Crowder, Louise Day, Sarah Downes, Nick Dudman, Amy Elliot, Katy Fray, Shaune Harrison, Charlotte Hayward, Eve Healey, Belinda Hodson, Beth John, Kristyan Mallett, Sharon Nicholas, Barney Nikolic, Cara Parry, Jemma Scott-Knox-Gore, Sophie Slotover, Lisa Tomblin, Jenna Wyatt
Departament artístic: Richard Cheal, Jane Clark, Matt Cooke, Jim Cornish, Martin Foley, Rosie Goodwin, Shane Harford, Jodie Jackman, Nicky Kaill, Matthew Kerly, Eduardo Lima, Elizabeth Loach, Catriona Maccann, Tony Marks, Sarah Marshall, Ginger McCarthy, Stephen McGregor, Ossie Merchant, Sonny Merchant, Stuart Meridew, Joe Monks, Steven Morris, Mitch Niclas, Amanda Pettett, Elicia Scales, Christian Short, Lucinda Sturgis, Stephen Swain, Ed Symon, Jason Torbett, Emma Vane, Ketan Waikar, Lauren Wakefield, Barry Wilkinson, Ben Wilkinson, Simon Wilkinson, Andrew Williamson, Ashley Winter, Lydia Fry, Emily Weekes
So: Nigel Albermaniche, Mark Appleby, Antony Bayman, Orin Beaton, Peter Burgis, Andrew Caller, John Casali, Ed Colyer, Gary Dodkin, James Doyle, Robert Edwards, Amy Felton, Michael Fentum, Samir Foco, Glen Gathard, Dominic Gibbs, Alistair Hawkins, Stuart Hilliker, Andy Kennedy, Rob Killick, Daniel Laurie, Jed Loughran, Mitch Low, James Mather, Jamie McPhee, Chris Murphy, Luke O'Connell, Jon Olive, Bjorn Ole Schroeder, Chris Sturmer, George Trevis, Stuart Wilson
Efectes especials: Jonathan Bullock, Richard Darwin, Andrew Ellinas, Philippe Gaulier, Pamela Goldammer, Claire Green, Matthew Harlow, Andy Hunt, Stephen Hutchinson, Ben James, Doug McCarthy, Noah Meddings, Luke Murphy, Ben Philips, John Richardson, Paul Stephenson, Jean-Francois Szlapka, Sally Wilson
Efectes visuals: Tony Abejuro, Paolo Acri, Nicolas Aithadi, Axel Akesson, Tim Alexander, Papavramides Alexandra, Dalia Al-Husseini, Ohkba Ameziane-Hassani, Arild Anfinnsen, Chris Armsden, Saqib Ashraf, Jonathan Attenborough, Lance Baetkey, Dan Bailey, Bhavika Bajpai, Richard Baker, Kamilla Bak, Michael Balog, Reuben Barkataki, David Basalla, Susanne Becker, Stephen Bennett, Petter Bergmark, Doug Bishop, Stacy Bissell, Axel Bonami, Mathieu Boucher, Yanick Bourgie, Jennifer Bowes, Steve Braggs, Jamie Briens, Neil Bristow, Andre Brizard, Jill Brooks, Mikael Brosset, Matt Brumit, Daniel Bryant, Izet Buco, Tim Burke, Andy Burmeister, Thomas J. Burton, Ivan Busquets, Naomi Butler, Ben Campbell, Alexandre Cancado, Jon Capleton, Marco Carboni, Jordi Cardus, Charmaine Chan, Fred Chapman, Richard Cheal, Ling Chen, Ian Chriss, Marc Chu, Wes Cilldhaire, Vincent Cirelli, Tim Civil, Helen Clare, Rhys Claringbull, Oli Clarke, Roberto Clochiatti, Kia Coates, Riccardo Coccia, Hayley Collins, Gemma Cooper, Loraine Cooper, Scott Cooper, Brenda Coxon, Daniel Craemer, Craig Crane, Ed Cross, Edward L. Dark, Marcello Da Silva, Alexandra Daunt Watney, Evan Davies, Adam Davis, Nick Davis, Stanley A. Dellimore, Bernie Demolski, Theo Diamantis, Ben Dickson, Michael Dohne, Chad Dombrova, Ferran Domenech, Andi Dorfan, Peter Doyle, Jan Dubberke, Bob Dunbar, Louis Dunlevy, Mohamed Effandi, Will Elsdale, Mattias Engström, Huw J. Evans, Stephen Evans, Joe Eveleigh, Ian Fallon, Kenneth Fanning, Sebastian Feldman, Brian Flynn, Nicola Fontana, James Foster, Mike Foyle, Paul J. Franklin, Nihal Friedel, James Furlong, Jigesh Gajjar, John J. Galloway, Juan Jesus Garcia, Nikos Gatos, Philippe Gaulier, Willi Geiger, Mikael Genachte-Lebail, David Gibbons, Ben Gillingham-Sutton, Nathalie Girard, Julian Gnass, Richard Gomes, Lisa Gonzalez, Bridget Maria Goodman, José Granell, Miguel Granell, Anthony Grant, Frank Gravatt, Dean Grubb, Branko Grujcic, Diego Guerrero, Jennifer Gutierrez, H Haden Hammond, Tyler Ham, Sam Hancock, Pete Hanson, Jeremy Hardin, Chris Hardman, Jacob Harris, Chris Hart, Trevor Hazel, Oliver Hearsey, Lionel Heath, Aeon Henderson, Simon Herden, Alex Hessler, Alex Hislop, Charity Hobbs-Wood, Sam Hodge, Mark Hodgkins, Robert Hoffmeister, Andrew Hogden, Vlad Holst, Graham Hopkins, Holly Gregory Horter, Brian Howald, Pete Howlett, Nikki Hughes, Antony Hunt, Matthew Hunt, Changeui Im, Andreas Jablonka, Matthew Jacques, Allan Torp Jensen, Lars Johansson, Helen Johnson, Stephen Jolley, Keith Jones, Marc Jones, Owen Jones, Alexander Kaminski, James D. Kelly, Aravinth Vince Kesavamoorthy, John Kilshaw, Jun Eun Kim, Dorian Knapp, Marcin Kolendo, Arek Komorowski, Benjamin Krebs, Keren Kurtz, Danius Kvedaras, Duncan Kuah Boon Kwang, Enrico Lambiase, Kirsty Lamb, Sam Lane, Lorenzo Lavatelli, Stafford Lawrence, Danny Lee, Marvin Lee, Sam Lee, Philippe Leprince, Luke Letkey, May Leung, John M. Levin, Gretchen Libby, Darryl Li, Michael Lim, Nerys Lincoln, Mattias Lindahl, Amy Lloyd, Gresham Lochner, Charlotte Loughnane, Steven Lovell, Doug Luberts, Thomas Luff, Damien Macé, Jessica Madsen, Angela Magrath, Dev Mannemela, Virgil Manning, Tony Man, Sophie Marfleet, Howard Margolius, Jan Maroske, David Marsh, Mark Masson, Javad Matoorian-Pour, Benjamin Mattress, Dirk Mauche, Marian Mavrovic, James McPherson, Dan McRae, Antonio Meazzini, Naveen Medaram, Alex Meddick, Gurel Mehmet, Charlotte Merrill, Ellen E. Miki, Jon Miller, John Moffatt, Oliver Money, Steven Moore, Harry Mukhopadhyay, Ryan Mullany, John Murphy, Marcell Nagy, Martin Newcombe, Elliot Newman, Nick New, Mark Newport, James P. Noon, Emma Norton, Ben O'Brien, Alban Orlhiac, Sam Osborne, Sona Pak, Viviana Palacios, Josh Paller, Christian Paradis, Puja Parikh, Michael Parkin, Hunter Parks, S. Scott Parrish, Isaac Partouche, Adam Paschke, Daniel Pastore, Nikita Patel, Emanuele Pavarotti, Tom Pegg, Miriam Pepper, Davide Pesare, Steve Petrie, Dawrath Phoue, Rob Pieke, Jason Pomerantz, Eric Ponton, Travis Porter, Bruce Powell, Andrew Proctor, Jacqui Purkess, Marc Purnell, Paul Raeburn, Benjamin Rayner, Adam Redford, Nicholas David Reed, Richard R. Reed, Tom Reed, Julia Reinhard, Tania Richard, Martin Riedel, Adriano Rinaldi, Laurent-Paul Robert, Ben Roberts, James William Roberts, Andy Robinson, Guillaume Rocheron, Sam Rowan, Craig Rowe, Alex Rutherford, Olivier Ryard, Gia Sadhwani, Rhys Salcombe, Miguel A. Salek, Mike Sanders, Steven Sandles, Sam Schwier, David Scott, Peter Seager, Alexander Seaman, Aatesh Shah, Chris Shaw, Gian Carlo Sherman, Dominic Sidoli, Joey Sila, Jared Simeth, Andrew Simmonds, Bruno Simões, Ken Sjogren, Michael Slater, Dan Snape, Alan So, Safari Sosebee, Jim Soukup, Malcolm Souter, Anthony Sparapani, Christoph Sprenger, Tom Steadman, Ben Steele, Tim Stern, Andy Stevens, Matteo Stirati, Paul Venn Stirling, Jelena Stojanovic, James Stone, Nigel Stone, Sheldon Stopsack, Giuseppe Tagliavini, Aaron Taylor, Scott Taylor, Sebastian Thinnes, Richard Thomas, Adrian Thompson, Lisa Thompson, Michael Adam Thompson, Ashley Tilley, Steve Tizzard, Richard Touch, Tim M. Townsend, Sanju Travis, Diego Trazzi, Chi Chung Tse, Melissa Tseng, Mario Ucci, John Van Der Zalm, Chris Van Dyck, Fani Vassiadi, Beck Veitch, Rickey Verma, Giuliano Dionisio Vigano', Andreas Vrhovsek, Christian Waite, Alexis Wajsbrot, Adam Walker, Orban Wallace, Karl Wardle, Kyle Ware, Ben Warner, James Waterson, Susan M. Weeks, Wendy Whaley, James Whitlam, Alexander Williams, Dan Wills, Chris Wilson, Doug Winder, Oliver Winwood, Kim Wiseman, Christian Wong, Eric Wong, Stephen Wong, Daniel Wood, Kim Worrall, Ian Wright, Elaine Wu, Alvin Yap, Teh-wei Yeh, Richard Yeomans, Gregory Yepes, Joyce Young, Leanne Young, Olly Young, Scott Younkin, Dean Yurke, Fabio Zangla, Jennie Zeiher, Dan Zelcs, Patrick Zentis, Martyn Drake, Andrew Scoggins, Heidy Villafane
Animació: Peta Bayley, Tracy Nicole Irwin, Florent Limouzin, Catherine Mullan, Chris Olsen, Joe Smith, Brian Ward, Robb Denovan
Càsting: Vanessa Baker, Brendan Donnison, Alice Searby
Vestuari: Mauricio Carneiro, Richard Davies, David J. Evans, Charlotte Finlay, Kate Frampton, Helen Jerome, Stephen Kill, Catherine Lovett, David McLaughlin, Neil Murphy, Stephanie Paul, Nicholas Roche-Gordon, Sunny Rowley, Timothy Shanahan, Rupert Steggle, Julie Telfer, Jo Van Schuppen
Departament editorial: Kate Baird, Bill Daly, Alex Fenn
Departament musical: Jeff Atmajian, Daryl Griffith, Robert Houston, Allan Jenkins, Alastair King, Ian Livingstone, Nelson Richard, John Williams
Departament de transports: Jim Adams, Nigel Birtchnell, Eddie Coleman, Paul Deluce, Warren Deluce, Peter Harvey, Jason Mortlock, Pete Newman, David Rosenbaum, Vivienne Rosenbaum, Karen Russell, David Speirs, Bill Walker, Terry Wilde, Kitch Young