En aquesta segona entrega del Sherlock Holmes d'en Guy Ritchie, el detectiu més famós de tots els temps (interpretat per Robert Downey Jr.) haurà d'afrontar els perillosos plans del seu enemic, el professor Moriarty (Jared Harris). En Holmes comptarà amb l'inestimable col·laboració del doctor Watson (Jude Law) i flirtejarà una altra vegada amb una dona de caràcter extrem: la Irene Adler (Rachel McAdams).
Disseny de personatges: Arthur Conan Doyle
Guió: Kieran Mulroney, Michele Mulroney
Coproducció: Steve Clark-Hall
Producció: Susan Downey, Dan Lin, Joel Silver, Lionel Wigram
Producció executiva: Scott Rudin
Música: Hans Zimmer
Fotografia: Philippe Rousselot
Muntatge: James Herbert
Càsting: Reg Poerscout-Edgerton
Disseny de producció: Sarah Greenwood
Direcció artística: James Foster, Nick Gottschalk, Matthew Gray, Niall Moroney
Vestuari: Jenny Beavan
Maquillatge: Sylvia Atkins, Michele Barber, Catherine Davies, Annette Field, Patt Foad, Charmaine Fuller, Teri Galati, Liberty Haynes, Davina Lamont, Ailsa Lawson, Laura Lilley, Sarah Jane Marks, Claire Matthews, Laura Milligan, Nina Pratley, Nikita Rae, Adrian Rigby, Karolina Scheepers, Matthew Smith, Nicola Springall, Bunny Stanway-Mayers, Tanya Webb, Helen Conroy, Jesse Rose Rogers
Departament artístic: Alison Adams, Shurouq Algusane, David Allcock, Will Ayres, Jim Barr, Arthur Beaudoin, Toby Britton, Ken Burnett, Christopher Chandler, Ben Collins, Simon Cook, Will Coubrough, Charlotte Crosbie, Julia Dehoff, Gabriela Dolenska, Jack Dyer, James Enright, Laurent Ferrie, Claire Fleming, Martin Griffiths, Neil Griffiths, Peter Hawkins, Stuart Read, Nicholas Henderson, Simon Hutchings, Eva Kuntz, Shay Leonard, Choi Ho Man, Peter Mann, Tony Marks, Gary Martin, Hugh McClelland, Stephen McGregor, Peter McKinstry, Elly Meyrick, Georgina Millett, Damian Mitchell, John Moolenschot, Steven Morris, Eva Onsrud, Claire Page, Martha Parker, Adrian Platt, Matthew Robinson, Cosmo Sarson, Elliot Scott, Tom Still, Daniel Swingler, Kristin Theyers, Vincent Thomas, Rebecca Todd, Chris Tooth, Remo Tozzi, Thomas Wingrove, Clare Winkworth, Lee Wiseman, Lotta Wolgers, Christopher Wyatt, Rohan Harris, Tom Sinden, Jon Ziman-Bright
So: Dillon Bennett, Jodie Campbell, Steve Finn, James Harrison, Chris Munro, Paul Munro, Becki Ponting, Oliver Tarney, Tristan Tarrant, Rachael Tate, Mark Taylor
Efectes especials: Charles Adcock, Dean Ford, Michaël Gojon dit Martin, Hugh Goodbody, Mark Holt, Mark Hutchinson, David Johns, Glenn Marsh, Paul McGuinness, Martin 'Marty' McLaughlin, Karl Openshaw
Efectes visuals: Nidhi Agarwal, Lee Alexander, Laya Armian, Adam Azmy, Nithin Babu, Michael Baker, Miles Barry, Angela Barson, Adrian Bell, Mark Beverton, Daniel Booty, Scott Bourne, Stuart Bullen, Jeffrey Burt, Daniel Cairnie, Manjoe Chan, Trevor Chong, Stanley A. Dellimore, Jan Dubberke, Boominathan Frances, Pawl Fulker, Jason Gagnon, Juan Jesus Garcia, Rob Garner, Sarah Gatefield, Mauro Giacomazzo, Erik Gronfeldt, Jan Guilfoyle, Ben Guthrie, Victoria Hodson, Adam Holmes, Bastian Hopfgarten, Chris Hunter, Paul Ingram, Marco Iozzi, Chas Jarrett, Christian Jelen, Mikael Jaeger Jensen, Viv Jim, Christopher Django Johnston, Marc Jones, Paddy Kelly, Arek Komorowski, Sujay Kumar G., Luka Leskovsek, Julian Levi, Justin Long, Natalie Lovatt, Sophie Marfleet, Declan McGuire, Ian Menzies, Mark Millena, Buhas Mohammedunny P., Leona Naidoo, Yoon See Ng, Chris Patrick O'Connell, Conrad Olson, Guo Kun Pan, Oleksandr Panaskevych, Puja Parikh, Steve Parsons, Radhika Patel, Matt Perrin, Richard Perry, Diego Piccinato, Sirio Quintavalle, Michael Ranalletta, Ambrish Rangan, Marc Rice, Mark Richardson, Colin Riley, Philip J. Robinson, Sherri Rogers, Marco Rolandi, Niels Roscher, Sam Salek, B.S. Rajkumar Sapate, Swati Shamsundar Malu, Cameron Sonerson, Susan Stewart, Nigel Stone, Bradey Strong, Alexander Swann, Trevor Tang, Mark Taylor, Mihail Temelkov, Joseph Thomas M., Vincent Thomas, Matthew Tinsley, Jonathan Turner, Vasantharajan.g.d, Damodaran Venkatesan, Mark Webb, Glenn Wells, Blake Winder, James Winnifrith, Anthony Wonsoff, Teh-wei Yeh, Michelle Yu, Chris Zammit
Càsting: Emma Callinan, Yannick Karcher
Vestuari: Russell Barnett, Mollie Barr, Dan Blacklock, Frieda Basso Boccabella, Anthony Brookman, Peter k Christopher, François-Louis Delfolie, Ian Foweraker, Mia Gray, Harriet Kendall, Jane Law, Calandra Meredith, Sophie Norinder, Steve O'Sullivan, Jennifer Powell, Kevin Pratten, Lora E. Revitt, Sunita Singh, Nathalie Karni
Departament editorial: Sam B. Bollinger, Siobhan Boyes, Philip Hedgecock, Todd Kleparski, Angus Munro, Tatjana Rhodes
Departament musical: Michael Connell, Alejandro de la Llosa, Karen Elliott, Michael Higham, Robert Houston, Steven Kofsky, Andrew Zack
Departament de transports: Piotr Chrzanowski, Mark Crowley, Lee Edwards, Darren Fenny, Paul Howitt, Colin Morgan, Chris Morse, Pete Newman, Jérôme Servant, Vincent Servant, Alexandre Thiery, Gerry Turner