El jove aventurer Sean Anderson (Josh Hutcherson) rep una trucada d'auxili que procedeix d'una illa misteriosa. De eft, en aquest indret... no hi hauria d'haver una illa! El padrastre d'en Sean, Hank (Dwayne Johnson), s'uneix a ell per protegir-lo. I també hi viatjaran un pilot d'helicòpter (Luis Guzmán) i la seva filla (Vanessa Hudgens). En arribar a l'illa veuran éssers monstruosos, muntanyes d'or, volcans i molts secrets que hauran de resoldre per tornar a casa sans i estalvis. Que comenci l'aventura!
Guió: Brian Gunn, Mark Gunn
Història original: Richard Outten, Brian Gunn, Mark Gunn
Producció executiva: Michael Bostick, Evan Turner, Marcus Viscidi
Producció associada: Adam Ellison
Producció: Beau Flynn, Charlotte Clay, Tripp Vinson
Música: Andrew Lockington
Fotografia: David Tattersall
Muntatge: David Rennie
Disseny de producció: Bill Boes
Direcció artística: Bruce Robert Hill
Vestuari: Denise Wingate
Maquillatge: Chantal Boom'la, Tarra D. Day, Lindsay Irish, James MacKinnon, Rachel Solow, Joy Zapata
Departament artístic: Vince Acree, Kip Bartlett, Tony Bohorquez, Anthony Carlino, Tom Castronovo, Jeff Clark, Richard M. Cole, Robert Danté Denne, Daren Dochterman, John Eaves, Chad S. Frey, Beth Giles, Elliott Glick, Frank J. Hart, Gregory Hill, Craig Hoffmann, J. Bryan Holloway, Michael Anthony Jackson, Scott Johnson, Gary A. Krakoff, Shane Ladd, Jenne Lee, Andrew H. Leung, B. Kyle Lewis, Jim Magdaleno, Kevin Mahoney, Alex McCarroll, Jonathan S. Morgan, Thomas A. Morris Jr., William Scot Noonan, James F. Oñate, Brett Phillips, Robin Richesson, Robert 'Lucky' Rieker, Isaia Robins, Barbara S. Shelton, Chad Simpson, Eric W. Skipper, Christopher Stanback, Lindsey Suggs, Darrell Tachibana, Miles Teves, Youa Vang, Gary Warshaw, Dana White, Adam Willis, Travis Witkowski, Liloa Wong
So: Ronni Brown, Timothy Cargioli, Colette Dahanne, Jenny Elsinger, Sean England, Jonathan Gaynor, Gregg Landaker, Richard Linke, Steve Maslow, Al Nelson, John Skoglund, Corey Tyler, Gwendolyn Yates Whittle, Greg Zimmerman
Efectes especials: Vince Acree, Roy K. Cancino, Nicholas Dawson, Michael E. Hall, Glenn Hetrick, David Hill, Jay Jones, Don Lanning, William Purcell, Sandra Stewart, James G. Thomas, Ross Young
Efectes visuals: Gary Abrahamian, Shane Acker, Jan Adamczyk, Jasmine Adams, Nidhi Agarwal, Gus R. Aguilera, Johann Albrecht, Lee Alexander, Paul Alexiou, Xuzhen An, Chris Anderson, Vasilis Antipas, Sean Araki, Nohemi Arciniega, Jose Astacio, Mark Austin, Christian Bahr, Christian Bahr, Jim Baker, Sam Baker, Jesse Balodis, Andrzej Bandurski, Marc H. Berrouet, Alex Berson, Juergen Billstein, Stefanie Blatt, Laurie Blavin, Derek Blume, Johannes Bogenhauser, Austin Bonang, Anto Bond, Tim Bowman, Peter Bowmar, Robby Branham, Kane Brassington, Stefan Braun, Mark Breakspear, Randy Brown, Stuart Bruzek, Shauna Bryan, Elika Burns, Nathaniel Caauwe, Craig Caton, Cheng Cheng, Mihaela Chifor, Suzanne Cipolletti, Mike Cisneros, Ian Clemmer, Dylan Cole, Matt Conway, Shane Cook, Michelle Cornwall, Joseph Creswell, Robert Cvengros, Steve Cypreos, Nick Damico, Enrico Damm, Steven Davies, Christian Deiß, Stanley A. Dellimore, Ben Dickson, Jason Donnelly, Greg Dora, Greg Downing, Scott Eade, Scott Edelstein, Chris Edwards, Jordan Emerick, Christian Emond, Marco Aurélio Engelmann Santos, David Espinoza, Sabine Ewers-Schorr, Marco Fanari, Anthony Fascione, Paul Fedor, Florian Fernandez, Eric Fernando, Erik Fernando, Felix Fissel, Marvin Fonacier, Boominathan Frances, Gabriel Franke, Jordan Freda, Stefan Galleithner, Gian Ganziano, Sinje Gebauer, Pätrick Gehlen, Harry S. George, Saneesh George, Mathew Giampa, Christian Godzik, Dan Goldman, Brittany Gonzales, Clark Graff, Kyle Gray, Josh Gridley, Johannes Gross, Michael Grund, Matti Grüner, Stefan Günther, Eli Guerron, Sebastian Haas, Michael Habenicht, Steven Hansen, Olafur Haraldsson, Silke Harbauer, Barbara Efthymiou Harris, Dietrich Hasse, Jessica Hee, Edward Helmers, Isaac Hingley, Michael Hipp, Bryan Hirota, Brian Holmes, Julie Holmes, Tia Hoshizaki, Jean-Francois Houde, Markus Hund, Stu Hunter, Gregor Höss, Hansoo Im, Marius Andre Jacobsen, Gemma James, Kristine-Joeann Jasper, Steven Qi Jin, Zahid Jiwa, Christopher Johnston, Felix Jorge, Jaimie Lee Jota, Dinesh K. Bishnoi, Jeffrey Kalmus, Jeff Kim, Kevin Kim, Ashley Koons, Christian Korneck, Simone Kraus, Patrick Kreuser, Max Krichenbauer, Katya Krotenko, Alexey Kuchinsky, Robert Kuczera, Jean Marc Ky, Juan Pablo Lampe, Michael Lankes, Kurt Lawson, Julius Lechner, Matt Lee, Erik Lehmann, Chun Ho Ray Leung, Julian Levi, Dean Lewandowski, Justin Lewers, Marcos Lohnefink, Lara Lom, Javier Lopez-Duprey, Anthony Lucero, Michal Maciejewski, Ben Mackey, Angela Magrath, Keywan Mahintorabi, Jennifer Maillet, Suraj Makhija, Maria Malo-Molina, Gabriel Mandala, Sophie Marfleet, Evans Mark, Natanya Marks, Toby Watson Martin, Lorenzo Mastrobuono, Trevin Matcek, Sean Mathiesen, Dan Mayer, Campbell McGrouther, Jason McKeeman, Pieter Mentz, Olaf Meyer, Justin Mijal, Nathan Millsap, Natt Mintrasak, Knuth Moede, Farhad Mohasseb, Guy A. Mussori, Knuth Möde, Leona Naidoo, Sue Nelson, Christine Neumann, Jason P. Nguyen, Catalin Niculescu, Teni Noravian, Erik Nordby, Mike Oakley, Jan Oberhauser, Silam Oezkaya, Sumit Pabbi, Brian Pace, Suresh Pandi, Hyun Bo Park, Steve Parsons, Steven Parsons, Ben Paschke, James Pina, Armando Plata, Rick Poley, Andrew Poole, Mark Prusten, Sophie Pruzsinszky, Franzisca Puppe, Ryan Purnell, Lance Ranzer, Dirk Reichelt, Tim Reischmann, Ti Ren, Trina Renee, Massimo Righi, Corinna Ringer, Niels Roscher, Felix Rothballer, Robert Rowles, Karl Rumpf, Sajeev Sadanandan, Nathan Santell, B.S. Rajkumar Sapate, Henry Sato, Daryl Sawchuk, Marlies Schacherl, Achim Schawer, Jakob Schmidt, Niel Schorfield, John Schratz, Hamish Schumacher, Sebastian Schäfer, Sebastian Schütt, Jay Seo, Maria Serrano, Richard Servello, Rasoul Shafeazadeh, Matthew Shaw, Boyd Shermis, Jan Sichermann, Tim Simon, Keith D. Simpson, Brian Smallwood, Patrick Smith, Tilo Spalke, Marion Spates, Christian Stanzel, Randy Starr, Paul Venn Stirling, Emanuel Strixner, Bradey Strong, Thomas Stölzle, Sung Wook Su, Albert Szostkiewicz, Emerick Tackett, Martin Tallosy, Trevor Tang, Sharellis Tatis, Patrick Taylor, Christian Te Kock, Damien Thaller, Jason Thielen, Cameron Thomas, Peter Toufidis, Duc Minh Tran, Phi Tran, Tong Tran, Shreedhra Trehan, Shannon Triplett, Robert Tucker, Graeme Tung, Barry Tuttle, Tharyn Valavanis, Mauricio Valderrama, John Van Der Zalm, David Vivaldini, Walter Volpatto, Yoshi Vu, Kustaa Vuori, Nashia Wachsman, Florian Waldenmaier, Eric Walls, Michael Waltl, Bill Wang, Steven Wang, Yanlin Wang, Rob Ward, Kyle Ware, Terri Watanabe, Philipp Welle, Mark Wendell, Bruno Werneck, Adina Wernstedt, Jeremy West, Larry White, Georg Wieland, Tom Williamson, Christopher Willis, Martin Wiseman, Patrick Wolf, Kai Wolter, Lonni Wong, Chris Wood, Michael Wortmann, Tzuen Wu, Trevor Wyatt, Donggue Yang, Zhao Yang, Genevieve Yee, Teh-wei Yeh, Hongyu Yin, Travis Yohnke, Kei Yoneoka, Oliver Zangenberg, Xingou Zhou, Dominik Zimmerle, Christoph Zollinger, Christian Zurcher, Henrik Zähringer, Chris B. Schnitzer
Animació: Daniel Lorenzo Alvarez, Eric Bates, Steve Cady, Anthony Rizzo, Jason Shum, Keith Patrick Turner
Càsting: Alexis Allen, Holly Dorff
Vestuari: John Casey, Sandra Collier, Krista Guggia
Departament editorial: Scott Anderson, Keith Brachmann, Ben Cox, Sally Anne Fuscoe, Matthew K. Hacker, Rick Ives, Jim Passon, Lara Ramirez, Bill Schultz, Spencer Turley
Departament musical: Stephen Lotwis, David Metzner, Neil Parfitt, Paul Pritchard, Andrea von Foerster, Michael White
Departament de transports: Ted Basso, Ty Church, Debbie Lane Hewett, E. Michael Hewett, Mark McNeill, George Nadian, Chris Raines, Richard C. Ryan, Scott Siler, Greg Stancil, Paul E. Stroh